This botanical contribution was created and realized in different contexts as IBSE methodology, starting from innovative botany didactic STEM experience (from macroscopic botanics to microscopic botanics) were involved different high school classes and universities, reflecting on the botany evolution and on the opportunities of this teaching methods can offer for the Botanical work innovatively, creatively, flexibly  to educate and to achieve learning successes. In all realized activities was important keeping the relationality alive with all students realizing different steps of an integrated botany STEM didactic itinerary with numerous experimental activities conceived and implemented in digital blended science teaching with microscope and macroscope botanical images. The educational actors of these project were aware that all innovative actitivies have long needed a process of profound innovation of botany teaching-learning methodologies that identify a different role for the science teacher, protagonist with students in the transformation processes in contamination between disciplines, promoter of knowledge that integrates soft skills and cognitive skills, far from «transmissive» didactic actions for learning by doing botanics in an innovative environmental education path using also model plant organism.