The Florida Panhandle is a unique region within the North American Coastal Plain (NACP), which is the 36th recognized biodiversity hotspot in the world. There are over 1,500 plant species endemic to the NACP, roughly 20% of which are present in the Florida Panhandle. The NACP more broadly, but particularly the Florida Panhandle, exemplifies the unique nature of the region as a biogeographic model– lacking stark elevational changes or clear barriers to gene flow aside from a few major rivers. I provide a review of what is known about this region’s high plant diversity and endemism by presenting a comprehensive review of biogeographic affinities as well as the complexities of these patterns at the phylogeographic level. My results show numerous overlapping affinities corresponding to distinct habitats found in the region such as sandhills, wet flatwoods, seepage-fed fens, limestone outcrops, and steephead ravines. These findings showcase this region as being at a crucial location historically for various migration events, but also the importance of the region in more recent times as home to multiple different refugia, which have ultimately contributed to the region's high diversity of plants. An overview of the region’s geology, history, and the overlapping disjunctions that seem to converge here will provide insight as to how these plant communities formed and changed through time. This in turn stresses the importance of the conservation of this region generally, while also pointing towards a better understanding of how ecosystem-level management can best take place in an area that is so richly mosaiced with multiple distinct plant communities which are separated by small changes in microclimate or topology.