The Neotropical clade of Lecythidaceae (Lecythidoideae) comprise 10 genera and more than 230 species of trees. We performed a phylogenomic analysis of Lecythidoideae, with focus on the Bertholletia clade, using custom target capture sequencing of 343 nuclear loci and nine informative plastome regions. Our sampling included 206 individuals from 133 described Neotropical species and ca.10 undescribed taxa. Our results confirmed monophyly of Grias, Gustavia, Couroupita, Allantoma, Cariniana, and Couratari. Within the Bertholletia clade, however, our work shows that Lecythis and Eschweilera are polyphyletic. Possible taxonomic changes in the family are dicussed.