Angiosperms dominate most land ecosystems. From shaping biomes and influencing the diversification of different organisms, to providing the base for human development, they are key elements in Earth’s history. However, given its huge diversity, with more than 300.000 species organised in nearly 14.000 genera, reconstructing the phylogenetic history of angiosperms is not an easy task. Either limited by sample availability or genetic representation, the complexity of angiosperms evolution is yet poorly assessed. Thanks to advances in sequencing technologies, we are now capable of harnessing the full potential of botanical collections to obtain high quality data from centuries-old specimens. Moreover, target sequence capture enables us to dive deeper into the nuclear genome, providing hundreds of truly independent loci. Here we present a phylogenetic tree of angiosperms based on 353 nuclear loci, including almost 8.000 genera (58%). With all orders and families included here for the first time in a nuclear phylogenomic framework, couple with a dense generic sampling, our tree supports the evaluation of the current classification system, redefining major clades, orders and families. Based on more than 200 fossils, we calibrated this phylogenetic tree and used this dated framework to study the diversification of angiosperms, unveiling an intricate pattern of diversification rates shifts. With the wide taxonomic and genomic coverage of our dataset, we emphasise the advantage of nuclear data to elucidate the relationship among flowering plants, paving the way towards the tree of life of angiosperms.